CAS 62-44-2 Painkiller Local Anesthetic Drugs Phenacetin White Raw Powder

CAS 62-44-2 Painkiller Local Anesthetic Drugs Phenacetin White Raw Powder

Description:

Phenacetin (or acetophenetidin) is a pain-relieving and fever-reducing drug, which was widely used between its introduction in 1887 and the 1983 ban imposed by the FDA on its use in the United States. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized as paracetamol (acetaminophen), which replaced it in some over-the-counter medications following the ban on phenacetin.

Specifications:

Chemical name: Phenacetin
Synonyms: N-(4-Ethoxyphenyl)acetamide; p-Acetophenetidide; 4-(Acetylamino)phenetole; 4-Ethoxy-1-acetylaminobenzene; 4-Ethoxyacetanilide; 4’-Ethoxyacetanilide; Aceto-4-phenetidine; Acetophenetidin; Acetophenetidine; Acetophenetin; Acetphenetidin; Fenidina; Fenina; Kalmin; N-Acetyl-4-ethoxyaniline; N-Acetyl-p-ethoxyaniline; N-Acetyl-p-phenetidine; NSC 7651; Pertonal; Phenacetine; Phenazetin; Phenedina; Phenidin; Phenin; p-Ethoxyacetanilide;
CAS Number: 62-44-2
Molecular form: C10H13NO2
Appearance: White Solid
Melting Point: 134-136°C
Mol. Weight: 179.22
Storage: Refrigerator
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine.
Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.

COA:

2D Structure:

Background and Benefits:

Phenacetin, introduced in 1887, was used principally as an analgesic, and was the first NSAID and fever reducer to go on the market. Typical doses of 300mg to 500mg a day result in an analgesic effect. Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action of the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type), intercostal neuralgia, and some forms of ataxia.

Phenacetin, and products containing phenacetin have been shown in an animal model to be carcinogenic. In humans, many case reports have implicated products containing phenacetin in urothelial neoplasms, especially transitional cell carcinoma of the renal pelvis. In one prospective series, phenacetin was associated with an increased risk of death due to urologic or renal diseases, death due to cancers, and death due to cardiovascular diseases.

In addition, people with glucose-6-phosphate dehydrogenase deficiency may experience acute hemolysis while taking this drug. Acute hemolysis is possible in the case of patients who develop an IgM response to Phenacetin leading to immune complexes that bind to erythrocytes in blood. The erythrocytes are then lysed when the complexes activate the complement cascade.

Phenacetin was widely used until the third quarter of the twentieth century, but was then largely replaced by non-carcinogenic drugs. Some branded phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Both propyphenazone and paracetamol are metabolites of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.

In Norway phenacetin is sold perscription over-the-counter with caffeine in a preparation know as Fenazon-Koffein. One tablet of Fenazon-Koffein contains 500mg phenacetin and 100mg caffeine along with filler products such as glucose.

How It Works:

Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.

It is metabolised in the body as paracetamol (acetaminophen).

Dosage:

Analgesic mixtures containing phenacetin were previously marketed as tablets or capsules containing between 150 and 300 mg phenacetin. Common combinations were: 150 mg phenacetin, 230 mg aspirin, and 15 or 30 mg caffeine; or 150 mg phenacetin, 230 mg aspirin, 30 mg caffeine, and 8, 15, 30, or 60 mg codeine phosphate. Phenacetin alone was also available in 250 and 300 mg doses as tablets, and up to 500 mg doses as powder. The usual dose was 300 mg 4-6 times per day, and the daily dose was not to exceed 2 g.

Professional Manufacture: Our mission is to help people who want to reach physical perfection. By offering a range of genuine and high quality oral and injectable steroids, anti-estrogens, weight loss drugs and sexual enhancers, LSW is creating a climate of reciprocal trust and respect with the bodybuilding and athletes’ community. For all those who are prepared and willing to realize body perfection, LSW will be your best choice.

Our Advantages:

1. Good reputation:

Our company is a leading chemical company in China, and has more than 16 years history. We have over 10 branch offices, all enjoy good reputation from worldwide customers.

2. High Quality&low price:

All of our products have top quality and high purity, since we are the factory, our price is competitive.

3. Multiple payment methods.

We have mutiple payment methods, T/T, Western Unoin, MoneyGram, and Bitcoin for your convenience.

4. Mass Stock:

In order to better serve our customers, we are preparing mass stock in our warehouse, we can always ship your parcel within 24 hours.

5. High customs clearance rate:

Through 16 years hard work, we have accumulated rich exporting experience to USA, UK, France, Italy, Germany,Spain, Brail, korea, India and so on.We will use special ways to disguise the goods, 98% customs clearance rate is guaranteed, if the delivery is not successful, we will resend for free.

6. Warm After service:

If you have any problems about the goods, do no hesitate to contact us, we can provide 7/24 service.

How to Proceed an Order:

Step1: When you intended to buy something, pls send me an inquiry by email, skype or whatsapp.

Step2: I will reply you with a quotation as soon as I receive you inquiry.

Step3: We will negotiate products, price, package, payment methods and so on.

Step4: You arrange the payment.

Step5: I will arrange the shipment after receiving you money.

Step6: The tracking number and the picture of the parcel will be sent to you.

Step7: Trace the tracking number on website until you receive the goods.

Step8: If you have any questions about the goods, pls contact me, i will try my best to satisfy you.

If you have any question pls feel free to contact me via:

Email: export@senwayer.com
Whats-app:+86-18186442580
Wickr me:yukis8888
We-chat:+86-18186442580
Tele-gram:+86-18186442580